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The impact of device-assisted therapies on the gut microbiome in Parkinson’s disease
- Source :
- Journal of Neurology. 269:780-795
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Microbiome feedbacks are proposed to influence Parkinson’s disease (PD) pathophysiology. A number of studies have evaluated the impact of oral medication on the gut microbiome (GM) in PD. However, the influence of PD device-assisted therapies (DATs) on the GM remains to be investigated. To profile acute gut microbial community alterations in response to PD DAT initiation. Clinical data and stool samples were collected from 21 PD patients initiating either deep brain stimulation (DBS) or levodopa–carbidopa intestinal gel (LCIG) and ten spousal healthy control (HC) subjects. 16S amplicon sequencing of stool DNA enabled comparison of temporal GM stability between groups and with clinical measures, including disease alterations relative to therapy initiation. We assessed GM response to therapy in the PD group by comparing pre-therapy (− 2 and 0 weeks) with post-therapy initiation timepoints (+ 2 and + 4 weeks) and HCs at baseline (0 weeks). Altered GM compositions were noted between the PD and HC groups at various taxonomic levels, including specific differences for DBS (overrepresentation of Clostridium_XlVa, Bilophila, Parabacteroides, Pseudoflavonifractor and underrepresentation of Dorea) and LCIG therapy (overrepresentation of Pseudoflavonifractor, Escherichia/Shigella, and underrepresentation of Gemmiger). Beta diversity changes were also found over the 4 week post-treatment initiation period. We report on initial short-term GM changes in response to the initiation of PD DATs. Prior to the introduction of the DAT, a PD-associated GM was observed. Following initiation of DAT, several DAT-specific changes in GM composition were identified, suggesting DATs can influence the GM in PD.
- Subjects :
- medicine.medical_specialty
Neurology
Parkinson's disease
Deep brain stimulation
biology
business.industry
medicine.medical_treatment
Disease
Gut flora
medicine.disease
biology.organism_classification
Gastroenterology
Pathophysiology
03 medical and health sciences
0302 clinical medicine
Oral administration
Internal medicine
Medicine
030212 general & internal medicine
Neurology (clinical)
Microbiome
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14321459 and 03405354
- Volume :
- 269
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology
- Accession number :
- edsair.doi...........b4bf9b1e76c8bb5c8dad474870fe9ebf