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Investigation of the Optimal Treatment Strategy for Atrial Fibrillation in Japan-The J-RHYTHM (Japanese Rhythm Management Trial for Atrial Fibrillation) Study Design
- Source :
- Circulation Journal. 67:738-741
- Publication Year :
- 2003
- Publisher :
- Japanese Circulation Society, 2003.
-
Abstract
- The Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM study) is a randomized comparative evaluation of rate control and rhythm control, both combined with antithrombotic therapy, as therapeutic strategies for the treatment of atrial fibrillation (AF). This study differs from the earlier AFFIRM and RACE studies in that it has a composite primary end-point representing mortality and also physical/psychological disablement (total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure requiring intravenous administration of diuretics, and patient disablement). Patients' will to change the therapeutic strategy to the other is also considered as an end-point representing disablement under the assigned strategy. The secondary end-point includes quality of life scores and the efficacy and safety of drugs used in treating AF. The J-RHYTHM study emphasizes patient-reported experience and perception of AF-specific disablement, and the safety of antiarrhythmics available in Japan; it will follow 2600 patients treated at more than 150 sites in Japan for a 3-year period.
- Subjects :
- medicine.medical_specialty
business.industry
Cerebral infarction
Optimal treatment
Atrial fibrillation
General Medicine
medicine.disease
Comparative evaluation
Quality of life
Heart failure
Antithrombotic
medicine
Cardiology and Cardiovascular Medicine
Intensive care medicine
business
Major bleeding
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi...........b48797cf05b91c41fddbf0367e4326a8
- Full Text :
- https://doi.org/10.1253/circj.67.738