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Investigation of the Optimal Treatment Strategy for Atrial Fibrillation in Japan-The J-RHYTHM (Japanese Rhythm Management Trial for Atrial Fibrillation) Study Design

Authors :
Tetsunori Saikawa
Itsuo Kodama
Makoto Hirai
Hideo Mitamura
Masayuki Sakurai
Hirotsugu Atarashi
Kaoru Sugi
Masahiko Fukatani
Yukihiro Koretsune
Takao Kato
Tohru Ohe
Yoshifusa Aizawa
Shiro Kamakura
Satoshi Ogawa
Yoshihisa Kurachi
Haruaki Nakaya
Tsutomu Yamazaki
Hiroshi Inoue
Takeshi Yamashita
Toshio Nakayama
Koichiro Kumagai
Ken Okumura
Source :
Circulation Journal. 67:738-741
Publication Year :
2003
Publisher :
Japanese Circulation Society, 2003.

Abstract

The Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM study) is a randomized comparative evaluation of rate control and rhythm control, both combined with antithrombotic therapy, as therapeutic strategies for the treatment of atrial fibrillation (AF). This study differs from the earlier AFFIRM and RACE studies in that it has a composite primary end-point representing mortality and also physical/psychological disablement (total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure requiring intravenous administration of diuretics, and patient disablement). Patients' will to change the therapeutic strategy to the other is also considered as an end-point representing disablement under the assigned strategy. The secondary end-point includes quality of life scores and the efficacy and safety of drugs used in treating AF. The J-RHYTHM study emphasizes patient-reported experience and perception of AF-specific disablement, and the safety of antiarrhythmics available in Japan; it will follow 2600 patients treated at more than 150 sites in Japan for a 3-year period.

Details

ISSN :
13474820 and 13469843
Volume :
67
Database :
OpenAIRE
Journal :
Circulation Journal
Accession number :
edsair.doi...........b48797cf05b91c41fddbf0367e4326a8
Full Text :
https://doi.org/10.1253/circj.67.738