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Protein inhibitor of activated STAT genes are differentially expressed in breast tumor tissues
- Source :
- Personalized Medicine. 16:277-285
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- Aim: Protein inhibitor of activated STAT ( PIAS) family includes transcriptional regulator proteins with SUMO E3 ligase activity. They regulate expression of several genes involved in cell proliferation, differentiation and survival. Method: We evaluated expression of PIAS1–4 genes in 54 breast cancer tissues and their paired adjacent noncancerous tissues. Results: PIAS2 and PIAS3 genes were significantly downregulated in tumoral tissues compared with adjacent noncancerous tissues. PIAS1–3 expressions were significantly lower in estrogen receptor (ER+) samples compared with ER- samples while PIAS4 had the opposite trend. PIAS3 expression was significantly higher in grade 1 samples compared with grade 2 samples. Conclusion: These findings highlight the role of PIAS genes in the pathogenesis of breast cancer and their association with determinants of response to antihormone therapies.
- Subjects :
- 0301 basic medicine
Pharmacology
biology
SUMO protein
Estrogen receptor
General Medicine
030105 genetics & heredity
medicine.disease
Ubiquitin ligase
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Breast cancer
030220 oncology & carcinogenesis
biology.protein
Cancer research
medicine
Transcriptional regulation
Molecular Medicine
Protein inhibitor of activated STAT
Gene
Subjects
Details
- ISSN :
- 1744828X and 17410541
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Personalized Medicine
- Accession number :
- edsair.doi...........b484125afc68143ed8247f1eb13e5e01