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Evaluation of vascular endothelial growth factor and nitric oxide associated with resveratrol supplementation

Authors :
Carla Ferreira
Ana Margarida Silva
Armando Caseiro
João Paulo Figueiredo
Telmo Pereira
Source :
European Journal of Public Health. 31
Publication Year :
2021
Publisher :
Oxford University Press (OUP), 2021.

Abstract

Background Resveratrol (3,4',5-trihydroxystilbene) (RSV) is one of the main non-flavonoid natural polyphenol compounds. Evidence suggests that RSV has a key role in preventing a variety of pathological processes because of its benefits, including anti-aging, anti-inflammatory, and cardiovascular disease prevention. Vascular endothelial growth factor (VEGF) is responsible for vasculogenesis and angiogenesis, and its expression is influenced by RSV. Vascular nitric oxide (NO) acts to relax smooth muscle cells by preventing thrombogenic processes. It has been shown in vitro and in vivo that RSV is involved in NO metabolism. The aim of this work was evaluate the effects of regular low-dose RSV consumption by determining serum VEGF and NO levels compared to a control group. Methods The study involved 27 clinically healthy individuals, divided into a control group (placebo) and an intervention group, supplemented with 100mg RSV/day. The VEGF levels were determined by slot blot technique and NO levels were determined by spectrophotometry before (T0) and after 30 days (T1) of supplementation. Results The VEGF and NO levels slightly decrease from T0 to T1 moment in both study groups, showing a higher decrease in both parameters in the control group compared to the intervention group, but the variation was not statistically significant. Conclusions Daily supplementation with RSV is associated with benefits at the VEGF level as well as at the vascular level. However, further studies with a larger number of participants are needed to confirm the effects of RSV on VEGF and NO levels.

Details

ISSN :
1464360X and 11011262
Volume :
31
Database :
OpenAIRE
Journal :
European Journal of Public Health
Accession number :
edsair.doi...........b44e5431e973f124f5056d198d05ee81