Back to Search
Start Over
Asymmetric Michael/hemiketalization of 5-hydroxy-2-methyl-4H-pyran-4-one to β,γ-unsaturated α-ketoesters catalyzed by a bifunctional rosin–indane amine thiourea catalyst
- Source :
- RSC Adv.. 4:42299-42307
- Publication Year :
- 2014
- Publisher :
- Royal Society of Chemistry (RSC), 2014.
-
Abstract
- A highly efficient asymmetric cascade reaction namely Michael-hemiketalization of 5-hydroxy-2-methyl-4H-pyran-4one to β,γ-unsaturated α-ketoesters has been developed using a chiral bifunctional rosin–indane amine thiourea catalyst. The products are obtained in excellent yields with a high degree of enantiomeric excess (up to 99% ee), in a short reaction time with low catalyst loading of 2.5 mol%.
Details
- ISSN :
- 20462069
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- RSC Adv.
- Accession number :
- edsair.doi...........b3f461b4f89a4bceb4536fede81c358b