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Role of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in the diagnosis of Neonatal Hypoxic-Ischemic Injury
- Source :
- Sohag Medical Journal. 24:120-129
- Publication Year :
- 2020
- Publisher :
- Egypts Presidential Specialized Council for Education and Scientific Research, 2020.
-
Abstract
- Background: Hypoxic Ischemic Encephalopathy is defined as a heterogeneous, clinically defined syndrome characterized by disturbed neurologic function in the earliest days of life in a neonate. Proton MR spectroscopy could reveal brain ischemic injuries in asphyxiated neonates earlier than T1- or T2-weighted MR imaging. MR spectroscopy and MR imaging is very important for the diagnosis of hypoxic-ischemic injury. Patients and Methods: A cross-sectional study. From December 2018 to December 2019, 50 full-term neonates were admitted to Neonatal Care Unit (NCU) in Sohag University Hospital with signs of HIE and referred to the Radio Diagnosis Department for brain imaging. MR imaging studies were performed using MRI system 1.5 tesla Achieva, Philips superconductive MRI system. Our MRI sequences 1. Axial T1WI. 2. Axial T2WI. 3. Axial FLAIR. 4. Axial DWI. 5. proton MR spectroscopyResults: The study included 50 neonates; 7 of them had normal MRI findings. The other 43 neonates showed different patterns of injury; 24 neonates showed a central pattern of injury,11 neonates show peripheral patterns of injury, While the other 8 neonates had shown both central and peripheral patterns of brain injury. Only 45 of examined neonates shows abnormal lactate peak. The sensitivity of MRS is 100%. However, the specificity is low 70 %, the overall accuracy is 60 %. Conclusion: MR spectroscopy is an accurate, sensitive and non-invasive method for early detection of perinatal ischemic brain injuries
- Subjects :
- In vivo magnetic resonance spectroscopy
Hypoxic ischemic
medicine.medical_specialty
medicine.diagnostic_test
business.industry
010102 general mathematics
Magnetic resonance imaging
Fluid-attenuated inversion recovery
University hospital
01 natural sciences
Hypoxic Ischemic Encephalopathy
Peripheral
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Medicine
030212 general & internal medicine
Radiology
0101 mathematics
business
Subjects
Details
- ISSN :
- 16878353
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Sohag Medical Journal
- Accession number :
- edsair.doi...........b3f317db20a1d8c638aa0ced2c897329