Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients withSOD1mutations

Authors :: Senda Ajroud-Driss
Claudia Morelli
Peter M. Andersen
Mona Shahbazi
Rahul Remanan
Stanley H. Appel
Kara G. Fields
Vincenzo Silani
Alberto Doretti
Luca Maderna
Ulrike Weiland
Stefan L. Marklund
Stefano Messina
Dale J. Lange
Jochen H. Weishaupt
Albert C. Ludolph
Source :: Annals of Neurology. 81:837-848
Publication Year :: 2017
Publisher :: Wiley, 2017.
Abstract: Objective: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose-dependent SOD1 reduction in cell culture systems. A previous p ...

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