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Prospective Pilot Evaluation of the Efficacy and Safety of Topical Ingenol Mebutate Gel for Localized Patch/Plaque Stage Mycosis Fungoides
- Source :
- The Open Dermatology Journal. 11:98-107
- Publication Year :
- 2017
- Publisher :
- Bentham Science Publishers Ltd., 2017.
-
Abstract
- Background: Mycosis Fungoides (MF) is the most frequent type of the primary cutaneous NK/T-cell lymphomas. Ingenol mebutate (IM) displays in vitro pro-apoptotic properties on neoplastic lymphocytes. Objectives: To evaluate the efficacy and safety of IM gel as topical treatment for MF. Materials and Methods: Ten male patients with longstanding classic type MF (n=9) and follicular MF (FMF; n=1), T2bN0M0B0, stage Ib, resistant to systemic methotrexate or acitretin therapies for at least 3 months, were included in this pilot study. In these patients, 11 target patch/plaque stage lesions with an area ≤ 25 cm2 were selected for IM therapy (0,05%, 2 weekly applications). The primary endpoint was the improvement of the CAILS scores. Biopsies were performed before and after treatment from 10 target lesions. Relapse rates were evaluated at 6 months. Results: The mean CAILS score of treated target lesions was reduced by 58.2%. The mean erythema, scaling and plaque elevation scores were improved by 73.6%, 93.9% and 97.9% (p Conclusion: IM gel warrants further investigation and development as a potential topical treatment for localized patch/plaque stage MF and FMF.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Mycosis fungoides
Ingenol Mebutate Gel
Patch/plaque stage mycosis fungoides
business.industry
Ingenol mebutate
Dermatology
medicine.disease
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
chemistry
Medicine
business
Cd8 antigen
Subjects
Details
- ISSN :
- 18743722
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- The Open Dermatology Journal
- Accession number :
- edsair.doi...........b3bebbba36ee4784771cc7876875a6bc