Platelet aggregation in Meniere's disease

β-thromboglobulin (β-TG) and platelet factor 4 (PF-4), which are indexes of intravascular platelet activation, were measured in patients with Meniere's disease. Serum concentrations of p-TG and PF-4 were elevated in 15% of the patients. Ticlopidine, a platelet aggregation inhibitor, decreased the serum levels of β-TG and PF-4, and was effective clinically in 69% of the cases. These findings suggest that platelet aggregation is one of the causes of vertigo in Meniere's disease.