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Neuroprotective efficacy of newly developed oximes in comparison with currently available oximes in tabun-poisoned rats
- Source :
- Journal of Applied Biomedicine. 13:39-46
- Publication Year :
- 2015
- Publisher :
- University of South Bohemia in Ceske Budejovice, 2015.
-
Abstract
- The ability of two newly developed oximes (K361, K378) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (310 μg/kg i.m.; 90% of LD50 value) were evaluated. Tabun-induced neurotoxicity was monitored by functional observational battery at 2 h following tabun challenge. The results indicate that all tested oximes combined with atropine enable tabun-poisoned rats to survive till the end of experiment. Both newly developed oximes (K361, K378) combined with atropine were able to decrease tabun-induced neurotoxicity in the case of sublethal poisonings although they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. Their ability to decrease tabun-induced acute neurotoxicity was slightly lower than that of trimedoxime and the oxime K203. Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes (especially trimedoxime and obidoxime) in the treatment of acute tabun poisonings.
- Subjects :
- Obidoxime
General Immunology and Microbiology
Aché
General Neuroscience
Health, Toxicology and Mutagenesis
Biomedical Engineering
Neurotoxicity
General Medicine
medicine.disease
Oxime
Neuroprotection
General Biochemistry, Genetics and Molecular Biology
language.human_language
chemistry.chemical_compound
Atropine
chemistry
Artificial Intelligence
Anesthesia
medicine
language
Trimedoxime
General Pharmacology, Toxicology and Pharmaceutics
General Agricultural and Biological Sciences
Tabun
medicine.drug
Subjects
Details
- ISSN :
- 12140287 and 1214021X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Biomedicine
- Accession number :
- edsair.doi...........b3922ba91e60affbfdf2db66202519ab