Fabrication of Gallic Acid Loaded SeNPs and their Neuroprotection Effect for Treatment of Ischemic Stroke

Ischemic stroke (IS) is a usual cerebrovascular ailment having high mortality and morbidity globally. The approaches for the treatment and prevention of cerebral ischemia–reperfusion injury (CIRI) are very limited. In this study, a delivery system of selenium nanoparticles loaded with gallic acid (GA-SeNPs) was developed utilizing ascorbic acid (AA) as a reducing agent and gallic acid (GA) as a capping agent. In pharmacokinetic study, GA-SeNPs clearly increases the AUC of the plasma concentration–time and extended GA half-life. In vitro effects of GA-SeNPs in the middle cerebral artery occlusion (MCAO) model and the oxygen glucose deprivation (OGD) model was measured. Finally, GA-SeNPs can be utilized as an efficient vehicle for delivery of GA in CIRI treatment.