Novel Flavonoids from the aerial parts of Unexplored and Endangered Wild nutmeg Species Myristica beddomei subsp. spherocarpa W.J. de Wilde

Chemoprofiling of the aerial parts of the unexplored wild nutmeg species M. beddomei subsp. Spherocarpa W.J. de Wilde led to the isolation of two new flavonoids, including an isoflavone 5,7-dihydroxy-3-(5'-hydroxybenzo[d](7',9')-dioxol-1'-yl)-4H-chromen-4-one (1) and a β-hydroxydihydrochalcone; (3(S)-hydroxy-3-phenyl-1-(2',4',6'-trihydroxyphenyl)propan-1-one (2) along with eleven known compounds (3-13) for the first time. The chemical structures of the isolates were elucidated by various spectroscopic analyses (1D and 2D NMR, HR-ESI-MS and IR). Chemotaxonomic significance of the isolates was discussed in detail. In addition the selected compounds were assessed for their in vitro cytotoxicity against human adenocarcinoma cell lines (MCF-7 and MDA-MB-231). Amongst malabaricones (3, 5-7) showed promising activity against both the cell lines whereas trimyristin (10) efficiently inhibited MCF-7 also partensein (8) and promalabaricone B (9) were found to be moderately toxic to MDA-MB-231 and MCF-7.