229: Effect of Treatment of Vitamin D Deficency/ Insuffiency (VDDI) on Mineral Metabolism in Non-Dialyzed Patients with CKD (ND-CKD)

EFFECT OF TREATMENT OF VITAMIN D DEFICENCY/ INSUFFIENCY (VDDI) ON MINERAL METABOLISM IN NON-DIALYZED PATIENTS WITH CKD (ND-CKD) Sudheer Sankar, Abdul Abdellatif, Zakaria Hamdan, John Gelfond, Fang-Ying Lin and Waje h Qunibi. Dept of Medicine. University of Texas Health Science Center. San Antonio, TX Vitamin D Deficiency/Insufficiency (VDDI) may be associated with hypocalcemia, increased PTH levels, reduced bone mineral density, and increased rates of hip fractures. We previously reported high prevalence of VDDI in ND-CKD. In this study, we report the effects of calcidiol supplementation on mineral metabolism in these patients. We followed K/DOQI treatment guidelines of VDDI in CKD patients. We obtained intact PTH, calcium, phosphorus, and vitamin D levels in 70 ND-CKD before and after treatment with ergocalciferol and reviewed their medical records and laboratory data. GFR was estimated by MDRD equation. CKD patients receiving vitamin D preparations other than ergocalciferol or phosphate binders were excluded. Of 225 ND-CKD patients with VDDI, 70 were treated with ergocalciferol. Mean age 57 years, 42% males. Preand posttreatment laboratory values are presented in table. Percentage achieved target vitamin D: 20%; 16%; 10%; and 30% for CKD stages 1&2, 3, 4 and 5 respectively. Percentage achieved PTH goal: 22%,17% and 11% for CKD stage 3,4 and 5 respectively. N 70 Pre-Rx Post-Rx P-value eGFR ± SD 29.8±16.6 26.6 ±14.9 0.0025 25OH VitD(ng/mL) ± SD 17.9±10.49 21.3 ±9.85 0.0438