Synthesis of N-alkylated benzo- and pyridothienopyrrolo-[1,2a][1,4]diazepin-6-ones acting as antidotes against the herbicide 2,4-D

We report N-alkylation reactions of pyrrolo[1,2-a][1,4]diazepin-6-ones annulated with a benzene ring or thieno[2,3-b]pyridine system. A range of new N5-substituted pyrrolodiazepines were synthesized, including compounds acting as antidotes against the herbicide 2,4-D.