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FORMULATION AND IN-VITRO EVALUATION OF ZOLMITRIPTAN IN SITU GEL FOR NASAL ADMINISTRATION

Authors :
Veena S. Belgamwar
Sanjay J. Surana
Payal H. Patil
D. A Patel
Source :
INDIAN DRUGS. 50:54-58
Publication Year :
2013
Publisher :
Indian Drug Manufacturers' Association (IDMA), 2013.

Abstract

The aim of present investigation was formulation and in-vitro evaluation of in situ gel for the nasal delivery of zolmitriptan. The in situ gel was prepared by temperature induced gelation technique using Pluronic with mucoadhesive polymer hydroxy propyl methyl cellulose K4 M in different ratios. The in situ gels so prepared were characterized and from the evaluation studies, batch PH2 was optimized and further subjected for stability studies at 30±2°C and 60±5% RH for 90 days. These formulations retained good stability at accelerated conditions and also did not show any remarkable damage to nasal mucosa in histopathological study. Owing to these properties it can be used as an effective delivery system for the nasal route.

Details

ISSN :
0019462X
Volume :
50
Database :
OpenAIRE
Journal :
INDIAN DRUGS
Accession number :
edsair.doi...........b29ec7d222a2f1591914f206af3f9dde
Full Text :
https://doi.org/10.53879/id.50.12.p0054