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Association of GLUT-1 (XbaI) Gene Polymorphism in Diabetes and Diabetes Nephropathy Patients of North Indian Population
- Source :
- International Journal of Research and Development in Pharmacy & Life Sciences. 8:1-6
- Publication Year :
- 2019
- Publisher :
- International Journal of Research and Development in Pharmacy and Life Sciences (IJRDPL), 2019.
-
Abstract
- Diabetic nephropathy (DN) is a chronic complication of both type 1 and type 2 diabetes. However, there is still inadequate understanding of the exact mechanism related to progressive diabetic renal disease. The GLUT-1 XbaI gene polymorphism in the glucose transporter has been suggested in the development of DN. However, its association with T2DM and DN is controversial and has not been established in different ethnic populations. To enhance the understanding of GLUT-1 XbaI gene polymorphism in the context of T2DM and DN. We investigated the possible genetic association of GLUT-1 XbaI polymorphism with T2DM and DN in North Indian population. 100 T2DM patients and 100 patients of DN with 100 healthy controls were included in the study. GLUT-1 XbaI polymorphism was determined by PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism). The obtained data showed no significant association between GLUT-1 XbaI gene polymorphism with T2DM and DN leading us to conclude that GLUT-1 XbaI gene polymorphism may not have major effects on T2DM and DN in North Indian population.
- Subjects :
- 0301 basic medicine
Genetics
endocrine system diseases
business.industry
nutritional and metabolic diseases
030209 endocrinology & metabolism
Type 2 diabetes
medicine.disease
Nephropathy
law.invention
Diabetic nephropathy
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
law
Diabetes mellitus
medicine
Gene polymorphism
Restriction fragment length polymorphism
business
Polymerase chain reaction
Genetic association
Subjects
Details
- ISSN :
- 22780238 and 2393932X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- International Journal of Research and Development in Pharmacy & Life Sciences
- Accession number :
- edsair.doi...........b27e89f77c694a6e972bccb23c402276