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Nanosized cancer cell-targeted polymeric immunomicelles loaded with superparamagnetic iron oxide nanoparticles
- Source :
- Journal of Nanoparticle Research. 11:1777-1785
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Stable 30–50 nm polymeric polyethylene glycol–phosphatidylethanolamine (PEG–PE)-based micelles entrapping superparamagnetic iron oxide nanoparticles (SPION) have been prepared. At similar concentrations of SPION, the SPION-micelles had significantly better magnetic resonance imaging (MRI) T2 relaxation signal compared to ‘plain’ SPION. Freeze-fracture electron microscopy confirmed SPION entrapment in the lipid core of the PEG–PE micelles. To enhance the targeting capability of these micelles, their surface was modified with the cancer cell-specific anti-nucleosome monoclonal antibody 2C5 (mAb 2C5). Such mAb 2C5-SPION immunomicelles demonstrated specific binding with cancer cells in vitro and were able to bring more SPION to the cancer cells thus demonstrating the potential to be used as targeted MRI contrast agents for tumor imaging.
- Subjects :
- Materials science
Superparamagnetic iron oxide nanoparticles
medicine.drug_class
MRI contrast agent
technology, industry, and agriculture
Bioengineering
Nanotechnology
General Chemistry
Condensed Matter Physics
Monoclonal antibody
Micelle
Atomic and Molecular Physics, and Optics
In vitro
Modeling and Simulation
Cancer cell
medicine
Biophysics
Nanomedicine
General Materials Science
Lipid core
Subjects
Details
- ISSN :
- 1572896X and 13880764
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Nanoparticle Research
- Accession number :
- edsair.doi...........b2764e8d6a233913525b12e454cf3de1