ChemInform Abstract: Synthesis of a Photoaffinity Analogue of Phosphatidylinositol 3,4- Bisphosphate, an Effector in the Phosphoinositide 3-Kinase Signaling Pathway

A Ferrier rearrangement strategy starting from α-d-glucose gave a protected inositol, which after coupling to a chiral diacylglycerol phosphoramidite, provided a tritium-labeled, benzophenone-containing derivative of P-l-(O-aminopropyl) linked dipalmitoyl PtdIns(3,4)P2.