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Semantic segmentation for prostate cancer grading by convolutional neural networks
- Source :
- Medical Imaging: Digital Pathology
- Publication Year :
- 2018
- Publisher :
- SPIE, 2018.
-
Abstract
- Certain pathology workflows, such as classification and grading of prostate adenocarcinoma according to the Gleason grade scheme, stand to gain speed and objectivity by incorporating contemporary digital image analysis methods. We compiled a dataset of 513 high resolution image tiles from primary prostate adenocarcinoma wherein individual glands and stroma were demarcated and graded by hand. With this unique dataset, we tested four Convolutional Neural Network architectures including FCN-8s, two SegNet variants, and multi-scale U-Net for performance in semantic segmentation of high- and low-grade tumors. In a 5-fold cross-validation experiment, the FCN-8s architecture achieved a mIOU of 0.759 and an accuracy of 0.87, while the less complex U-Net architecture achieved a mIOU of 0.738 and accuracy of 0.885. The FCN-8s architecture applied to whole slide images not used for training achieved a mIOU of 0.857 in annotated tumor foci with a multiresolution processing time averaging 11 minutes per slide. The three architectures tested on whole slides all achieved areas under the Receiver Operating Characteristic curve near 1, strongly demonstrating the suitability of semantic segmentation Convolutional Neural Networks for detecting and grading prostate cancer foci in radical prostatectomies.
- Subjects :
- 0301 basic medicine
Prostate adenocarcinoma
Receiver operating characteristic
Computer science
business.industry
Digital pathology
Pattern recognition
medicine.disease
Gleason grade
Convolutional neural network
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
030104 developmental biology
0302 clinical medicine
medicine
Segmentation
Artificial intelligence
business
Grading (tumors)
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Medical Imaging 2018: Digital Pathology
- Accession number :
- edsair.doi...........b18888edd86d9912f84a131af8843b10