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Abstract A54: Downregulation of hepatocyte growth factor activator inhibitor-2 is involved in the progression of prostate cancer cells

Authors :
Pei-Wen Hsiao
Hsin-Yi Shyu
Ming-Shyue Lee
Shang-Ru Wu
Tai-Shan Cheng
Shao-Wei Lan
Chun-Jung Ko
Source :
Cancer Research. 71:A54-A54
Publication Year :
2011
Publisher :
American Association for Cancer Research (AACR), 2011.

Abstract

Dysregulation of pericellular proteolysis has been strongly involved in tumorigenesis. In this study, we delineated the role of hepatocyte growth factor activator inhibitor-2 (HAI-2) in prostate cancer cell invasion and tumorigenicity within a human prostate cancer progression model (103E, N1, and N2 cells). This model was newly established by a serial of intraprostatic propagation of a human prostate cancer 103E cell line and isolation of the metastatic cells from nearby lymph nodes. The invasion capability of these cells was gradually increased after the serial isolations (103E Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A54.

Details

ISSN :
15387445 and 00085472
Volume :
71
Database :
OpenAIRE
Journal :
Cancer Research
Accession number :
edsair.doi...........b183224a3aaf4e49e9088a81bb5c56b2