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Reaction of 8,8-dibromobicyclo[5.1.0]octanes with higher-order organocuprates
- Source :
- Chemical and Pharmaceutical Bulletin. 35:1777-1784
- Publication Year :
- 1987
- Publisher :
- Pharmaceutical Society of Japan, 1987.
-
Abstract
- Treatment of 8, 8-dibromobicyclo [5.1.0] octanes (A) with a higher order organocuprate prepared from cuprous thiocyanate (method A) or cuprous cyanide (method B) and methyllithium, followed by the addition of methyl iodide in situ, readily afforded 8, 8-dimethylbicyclo [5.1.0] octanes (B) in good yields. The results are summarized in Table I. Interestingly, reaction of the cisdibromides (4 and 19) under the present conditions gave tricyclic compounds (15 and 16, and 20, respectively)
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi...........b18149136f806c70a82f05ad6818c63f