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Retinale Schäden durch flüssige Perfluorkarbone – eine Frage des spezifischen Gewichts? Intraokulare Druckspitzen und Scherkräfte
- Source :
- Klinische Monatsblätter für Augenheilkunde. 226:38-47
- Publication Year :
- 2009
- Publisher :
- Georg Thieme Verlag KG, 2009.
-
Abstract
- BACKGROUND: Perfluorocarbon liquids (PFCL) cause retinal damage when used as long-term ocular endotamponades. Whether these changes are related to the mechanical or to the chemical properties of PFCL is unclear. The purpose of this study was to evaluate pressure spikes or shearing forces during endotamponade with PFCL and standardised eye movements. MATERIAL AND METHODS: Part 1: In an eye model the resulting pressure forces of 6 PFCL were measured at four different sites during standardised eye movements. Part 2: Shearing forces were determined in a plexiglass eye model and the resulting tangential forces at the PFCL-retina interface were calculated. Part 3: Rabbit eyes were vitrectomised and filled with light and heavy fluorocarbons for 6 weeks. Subsequently, the retina were examined histologically and by immunohistochemistry. RESULTS: With increasing filling of the eye model, the maximum of the pressure peaks moved from the inferior wall of the eye model to the lateral eye walls. For perfluorodecalin (PFD) the highest pressure peak was 407 Pa with a 75 % filling of the vitreous cavity. The lowest pressure peak was 314 Pa with a 50 % filling of hexafluoropropene oxide. Shearing forces for standardised accelerations were dependent on viscosity and ranged between 0.87 mN/m 2 (perfluorohexyloctane) and 8055 mN/m 2 (hexafluoropropene oxide). Part 3: Histological and immunohistochemical analyses did not reveal pressure-related damage or any difference between the effects of the different tamponades in vivo. CONCLUSION: In comparison with physiological dynamic and static pressure peaks, the measured mechanical forces induced by intraocular PFCL tamponades are low. Specific gravity and mechanical damage by intraocular PFCL as a cause of retinal damage seem unlikely. Animal studies underline these findings.
- Subjects :
- Retina
Intraocular pressure
Materials science
genetic structures
Retinal damage
business.industry
Shear force
Static pressure
eye diseases
Ophthalmology
chemistry.chemical_compound
Perfluorodecalin
medicine.anatomical_structure
Optics
chemistry
medicine
sense organs
Endotamponade
business
Biomedical engineering
Specific gravity
Subjects
Details
- ISSN :
- 14393999 and 00232165
- Volume :
- 226
- Database :
- OpenAIRE
- Journal :
- Klinische Monatsblätter für Augenheilkunde
- Accession number :
- edsair.doi...........b1747e4b37ad1c3afa1a2482cba63604