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Feasibility of re-biopsy and EGFR mutation analysis in patients with non-small cell lung cancer
- Source :
- Thoracic Cancer. 9:856-864
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND In cases of EGFR-tyrosine kinase inhibitor (TKI) failure, re-biopsy may be useful to understand resistance mechanisms and guide further treatment decisions. However, performing re-biopsy is challenging because of several hurdles. We assessed the feasibility of re-biopsy in advanced non-small cell lung cancer (NSCLC) patients in real-world clinical practice. METHODS We retrospectively reviewed the clinical and pathologic data of advanced NSCLC patients who experienced disease progression after previous treatment with EGFR-TKIs at a single tertiary hospital in Korea between January 2014 and December 2016. Re-biopsy specimens included small biopsy, surgical tissue, or liquid-based cytology. EGFR mutation was tested using peptide nucleic acid-mediated clamping PCR. RESULTS Of the 230 NSCLC patients that experienced progression after EGFR-TKI therapy, 105 (45.7%) underwent re-biopsy. Re-biopsy was successfully performed in 94 (89.5%) patients, and 11 patients were diagnosed with no malignancy. The complication rate was 8.6%, including seven cases of pneumothorax. EGFR mutation testing was performed on 75 patients using re-biopsy specimens. Of the 57 patients who had sensitizing mutations at diagnosis, T790M mutations were found in 19 (33.3%), while 38 (66.7%) had no T790M mutation. Multivariate analysis showed that the re-biopsy group was younger (P = 0.002) and exhibited a previous response to EGFR-TKIs (P
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
medicine.medical_specialty
Multivariate analysis
medicine.diagnostic_test
business.industry
General Medicine
medicine.disease
Malignancy
respiratory tract diseases
03 medical and health sciences
T790M
030104 developmental biology
0302 clinical medicine
Pneumothorax
Egfr mutation
030220 oncology & carcinogenesis
Internal medicine
Cytology
Biopsy
medicine
business
Lung cancer
Subjects
Details
- ISSN :
- 17597706
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Thoracic Cancer
- Accession number :
- edsair.doi...........b111808c230a701111463fb1f3e5c4ef
- Full Text :
- https://doi.org/10.1111/1759-7714.12762