ChemInform Abstract: Unexpected Rearrangement During Biomimetic Entry Toward a Taxane Skeleton

Authors :: Hiroshi Imagawa
Ikumi Hyodo
Kohsuke Asoh
Hidetoshi Yamada
Miho Takeji
Mugio Nishizawa
Eiko Morikuni
Source :: ChemInform. 29
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Bicyclo[9.3.1]pentadecatriene derivative 4 which corresponds to a precursor of taxol in a biomimetic entry was constructed by means of TiCl 4 Zn promoted McMurry cyclization and Mitsunobu inversion. Treatment of 4 with mercuric triflate afforded an unexpected rearrangement-transannular cyclization product 5 .

Subjects :: chemistry.chemical_compound
Mercuric triflate
chemistry
Bicyclic molecule
Stereochemistry
General Medicine
Derivative (chemistry)

Full Text Access

Tools