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Visible-Light-Promoted Carboimination of Unactivated Alkenes for the Synthesis of Densely Functionalized Pyrroline Derivatives

Authors :
Shengjin Song
Teck-Peng Loh
Lu Ye
Chao Feng
Jia-Hao Xie
Sai-Hu Cai
Source :
ACS Catalysis. 6:5571-5574
Publication Year :
2016
Publisher :
American Chemical Society (ACS), 2016.

Abstract

An efficient strategy which integrates visible-light-induced iminyl-radical formation with carboimination of unactivated alkenes has been developed for the easy access of densely functionalized pyrroline derivatives. With fac-[Ir(ppy)3] as photoredox catalyst, the acyl oximes were converted into iminyl radical intermediates by one electron reduction, and evolve through a cascade of intramolecular cyclization and intermolecular carbon radical trapping to give the functionalized pyrrolines. The utilization of silyl enol ethers as coupling partners not only allows the introduction of synthetically useful ketone functionalities but also renders catalyst regeneration without any external reductants. This protocol is characterized by its mild reaction conditions and the tolerance of a broad range of functionalities.

Details

ISSN :
21555435
Volume :
6
Database :
OpenAIRE
Journal :
ACS Catalysis
Accession number :
edsair.doi...........b01f2d63f05a9a101c8c1021d2e4dcea
Full Text :
https://doi.org/10.1021/acscatal.6b01230