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Temperature-induced structural diversity of two coordination polymers: magnetic properties and treatment activity on depression via activating the nigrostriatal dopamine D2 receptor
- Source :
- Journal of Polymer Research. 28
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- By applying the mixed-ligand approach, two new Co(II)-including coordination polymers (CPs) {[Co2(Glu)2(1,4-mbix)2(H2O)2]·H2O}n, (1) and {[Co(Glu)(1,4-mbix)]·4H2O}n (2), were formed by taking glutarate (Glu2−) blended with 1,4-bis [(2-methyl-1H-imidazol-1-yl)methyl]benzene (1,4-mbix) by using different reaction temperatures. The as-prepared complexes were evaluated through IR spectroscopy, elemental analysis, powder X-ray diffraction analysis (PXRD), TG analysis and single-crystal X-ray diffraction. The structural characterization results show that complex 1 features a 3D framework structure with a four-connected neb-type topology, while complex 2 demonstrates a 2D layered structure with a four-connected sql-type topology. The magnetic studies show that compounds 1 and 2 have antiferromagnetic coupling between the adjacent metallic ions. Their biological activity on depression animal model was determined and the mechanism was detected. Firstly, the depression animal model was built and the compounds were given for indicated treatment. The nigrostriatal dopamine D2 receptor content was measured by real time reverse transcription-polymerase chain reaction (RT-PCR). The content of the 5-hydroxy trptamine (5-HT) and Norepinephrine (NE) was measured by enzyme linked immunosorbent assay (ELISA) detection kit after compounds treatment.
- Subjects :
- chemistry.chemical_classification
Materials science
Polymers and Plastics
Organic Chemistry
Infrared spectroscopy
Biological activity
02 engineering and technology
Polymer
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
0104 chemical sciences
Ion
Metal
Crystallography
chemistry.chemical_compound
chemistry
visual_art
Dopamine receptor D2
Materials Chemistry
visual_art.visual_art_medium
0210 nano-technology
Benzene
Powder diffraction
Subjects
Details
- ISSN :
- 15728935 and 10229760
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Polymer Research
- Accession number :
- edsair.doi...........b01c928f60fcfc9ad839a7aeabdb7776