The Use of a Bifunctional Copper Catalyst in the Cross-Coupling Reactions of Aryl and Heteroaryl Halides with Terminal Alkynes

Copper-catalyzed cross-coupling reactions of aryl halides and heteroaryl halides with terminal alkynes were carried out in DMF at 110–130 °C to provide the corresponding coupling products in satisfactory-to-good yields by using inexpensive 8-hydoxyquinoline as the ligand. Noteworthy is that the bifunctional copper catalyst was successfully applied in this alkynylation reaction for the first time.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)