18FDG PET for grading malignancy in thymic epithelial tumors: Significant differences in 18FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: Preliminary study

Purpose To evaluate 18 F-fluorodeoxyglucose (FDG) uptake to predict the malignant nature and analyze the correlation between FDG uptake and expression of glucose transporter 1 (Glut-1) and hexokinase II (HK-II) in thymic epithelial tumors. Materials and methods Eleven patients with a thymic epithelial tumor who underwent FDG PET/CT before therapy were reviewed. The thymic tumors were classified by the WHO histological classification and Masaoka clinical staging. Comparison of maximum standardized uptake value (SUV max ) of the lesion was made between the low-risk (Type A, AB and B1) and high-risk {Type B2, B3 and C (thymic cancer)} groups and among clinical stages. Expression of Glut-1 and HK-II was analyzed immunohistochemically. Results All 11 tumors showed FDG uptake visually. SUV max was significantly higher in the high-risk group ( n = 5, 5.24 ± 2.44) than the low-risk group ( n = 6, 3.05 ± 0.55) ( P = 0.008). Staining scores of both Glut-1 and HK-II were significantly higher in the high-risk group than in the low-risk group (Glut1: P = 0.034 and HK-II: P = 0.036). There were no significant differences in SUV max ( P = 0.11), Glut-1 ( P = 0.35) and HK-II scores ( P = 0.29) among clinical stages. SUV max was significantly correlated to each of the staining scores of Glut-1 ( ρ = 0.68, P = 0.031) and HK-II ( ρ = 0.72, P = 0.024). Conclusion These preliminary results support the previously published view that SUV max may be useful to predict the malignant nature of thymic epitherial tumors and suggest that the degree of FDG uptake in the thymic epitherial tumors is closely related to the amount of Glut-1 and HK-II in the tumor.