HP(O)Ph2/H2O-promoted hydrodefluorination of trifluoromethyl alkenes

Authors :: Xue-Qiang Chu
Li-Wen Sun
Yu-Lan Chen
Jia-Wei Chen
Xuan Ying
Mengtao Ma
Zhi-Liang Shen
Source :: Green Chemistry. 24:2777-2782
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: An efficient transition-metal-free hydrodefluorination reaction of trifluoromethyl alkenes for accessing gem-difluoroalkenes is developed. It was surprising to find that the phosphoryl anion is able to mediate the defluorination.