AN ULTRASOUND MEDIATED GREEN SYNTHESIS OF 2-PYRAZOLINE DERIVATIVES

Pyrazolines are prominent nitrogen-containing heterocyclic compounds and therefore, various procedures have been worked out for their synthesis. After the pioneering work of Fischer and Knoevenagel in the 19th century, the reaction of α, β-unsaturated aldehydes and ketones with phenylhydrazine in acetic acid by reuxing became one of the most popular methods for the preparation of 2-pyrazolines. Aseries of substituted 2- pyrazolines was synthesized by ultrasound irradiated method to nd out cleaner/ greener approaches.