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[Untitled]

Authors :
Eric J. Lien
Pou-Hsiung Wang
Mary B. V. Hui
Samitendu Banerjee
Hua Gao
Partha Nandy
Source :
Pharmaceutical Research. :1006-1012
Publication Year :
1991
Publisher :
Springer Science and Business Media LLC, 1991.

Abstract

Substituted Schiff bases of l-amino-3-hydroxyguanidine (SB-HAG) were tested for the first time against noninfected T4 lymphocytes (CEM-6 cells) and the same cell line infected by HIV-1 in vitro. Twenty-one of 23 compounds at micromolar levels did not inhibit the growth of the noninfected T4 cells, suggesting minimal cytotoxicity. The antiviral effects of these compounds in a micromolar concentration range have been shown to be nonsignificant (

Subjects

Subjects :
Pharmacology
Quantitative structure–activity relationship
Stereochemistry
Lymphocyte
Organic Chemistry
Pharmacology toxicology
Human immunodeficiency virus (HIV)
Pharmaceutical Science
Biology
medicine.disease_cause
In vitro
medicine.anatomical_structure
Cell culture
medicine
Molecular Medicine
Pharmacology (medical)
T4 Lymphocytes
Cytotoxicity
Biotechnology

Details

ISSN :
07248741
Database :
OpenAIRE
Journal :
Pharmaceutical Research
Accession number :
edsair.doi...........af61493a8c86a5dad4c96c5168f881d0
Full Text :
https://doi.org/10.1023/a:1015852907149
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