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Pubinernoid A and Apo-9′-fucoxanthinone, Secondary Metabolites from a Gorgonian Coral Pinnigorgia sp
- Source :
- Natural Product Communications. 11:1934578X1601100
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- The structures of pubinernoid A (1) and apo-9′-fucoxanthinone (2), isolated from a gorgonian coral Pinnigorgia sp., were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of known compounds. This is the first report of 1 and 2 from an animal source. Apo-9′-fucoxanthinone (2) displayed a significant inhibitory effect on the release of elastase by human neutrophils, with an IC50 value of 5.75 μM.
- Subjects :
- Pharmacology
biology
010405 organic chemistry
Chemistry
Coral
Elastase
Plant Science
General Medicine
biology.organism_classification
01 natural sciences
0104 chemical sciences
Terpene
010404 medicinal & biomolecular chemistry
Gorgonian
Complementary and alternative medicine
Biochemistry
Anthozoa
Drug Discovery
Secondary metabolism
Pancreatic elastase
IC50
Subjects
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........af53c1734a976bd5c22027568ae6e36d