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Indomethacin-induced small intestinal injury is ameliorated by cilostazol, a specific PDE-3 inhibitor

Indomethacin-induced small intestinal injury is ameliorated by cilostazol, a specific PDE-3 inhibitor

Authors :
Atsushi Kawaguchi
Shigeaki Nagao
Kengo Tomita
Yoshikiyo Okada
Ryota Hokari
Masaaki Higashiyama
Chikako Watanabe
Chie Kurihara
Shunsuke Komoto
Soichiro Miura
Toshihide Ueda
Source :
Scandinavian Journal of Gastroenterology. 47:993-1002
Publication Year :
2012
Publisher :
Informa UK Limited, 2012.

Abstract

Background. Neutrophil migration, one of the major factors predisposing to nonsteroidal anti-inflammatory drugs (NSAIDs)-induced intestinal lesions, consists of several steps, including interaction with P-selectin from platelets. Cilostazol, a specific phosphodiesterase (PDE)-3 inhibitor, suppresses the expression of P-selectin from platelets and reduces interaction between platelets and leukocytes, leading to inflammatory amelioration in several disease models. We tried to clarify the therapeutic effectiveness of cilostazol for NSAID-induced small intestinal lesions. Subjects and methods. 1) Anti-PSGL-1 antibody (2 mg/kg) or cilostazol (100 mg/kg) was administered to mice one hour before Indomethacin (IND, 2.5 mg/kg) administration for 4 days to evaluate small intestinal lesions. 2) IND-induced migratory behaviors of neutrophils and platelets were evaluated in intestinal vessels by an intravital microscopy. Results. i) IND induced small intestinal lesions with an increase in MPO activity. Anti-P...

Details

ISSN :
15027708 and 00365521
Volume :
47
Database :
OpenAIRE
Journal :
Scandinavian Journal of Gastroenterology
Accession number :
edsair.doi...........af1e40fc187e7b6f22ddca5fc0d5d4f5
Full Text :
https://doi.org/10.3109/00365521.2012.690043