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Copper-Catalyzed Formal [3 + 3] Annulations of Arylketoximes and o-Fluorobenzaldehydes: An Entry to Quinoline Compounds

Authors :
Huawen Huang
Guo-Jun Deng
Zhenhua Xu
Hongbiao Chen
Source :
Organic Letters. 23:936-942
Publication Year :
2021
Publisher :
American Chemical Society (ACS), 2021.

Abstract

A copper-based catalytic system has been developed to enable efficient cyclization of ketoxime acetates with o-fluorobenzaldehydes. This protocol offers an efficient method for the synthesis of substituted quinoline derivatives with a broad range of compatible functionalities. The present system also provides a rapid access to synthetically and pharmaceutically useful quinoline-fused polycycles such as benzo[c]acridines.

Details

ISSN :
15237052 and 15237060
Volume :
23
Database :
OpenAIRE
Journal :
Organic Letters
Accession number :
edsair.doi...........aec56fcf2d1157552caeea0d5bac8bc2