Insulin sensitivity and brain reward activation in overweight Hispanic girls: a pilot study

Results: Comparing HC with NF, SI was inversely associated with activation in the anterior cingulate (r 2 = 0.65; P < 0.05), the insula (r 2 = 0.69; P < 0.05), the orbitofrontal cortex (r 2 = 0.74; P < 0.05), and the frontal and rolandic operculum (r 2 = 0.76; P < 0.001). Associations remained significant after adjustment for body mass index. Association of fasting insulin and cerebral activation disappeared after adjustment for waist circumference. Conclusion: In addition to weight loss, insulin sensitivity may pose an important target to regulate neural responses to food cues in the prevention of excessive weight gain.