5. Analysis of antiviral state in RD114 and A204 cells after interferon treatment

Interferon exerts antiviral and various non-antiviral activities on cells. For the development of the antiviral state in cells against exogenous infection of cytolytic viruses such as vesicular stomatitis virus and encephalomyocarditis virus (EMCV), induction of 2'-5'-oligo(A) synthetase or double-stranded (ds)-RNA-dependent protein kinase, or both, has been shown to have a crucial role (Revel 1979). However, in some cases, the antiviral effects of interferon are virus-specific (Nilsen et al. 1980; Samuel & Knutson 1981). Recently, different effects of mouse interferon on retrovirus production and on EM CV replication in a clonal cell line from NIH / 3T3 cells were reported (Gzarniecki et al. 1981).