The new 'one-flask' synthesis of 14C labelled 1-bromoalkanes - synthesis of 1-bromo [1-14c] heptane

Conditions were found for almost quantitative carboxylation of n-hexyllithium with 14CO2 to afford lithium [1-14C] heptanoate. It was then possible to perform the reaction sequence lithium [1-14C] heptanoate[1-14C] heptan-1-ol 1-bromo [1-14C] heptane in one flask without isolation of intermediates. In the “hot” synthesis 12,8 GBq (346 mCi) of 1-bromo [1-14C] heptane with radiochemical purity better than 97 % were prepared from Ba14CO3 in 81 % yield.