ATORVASTATIN COMBINED WITH PROBUCOL CAN REDUCE SERUM URIC ACID'S LEVEL DURING PERIOPERATIVE PERIOD OF INTERVENTION

Objectives To observe the effect of different doses of atorvastatin combined with different dose of probucol on the level of serum uric acid in patients undergoing coronary angiography or percutaneous coronary intervention (PCI). Methods 208 cases enrolled in our study were randomly divided into three groups: Standard combining treatment group (n=55): Atorvastatin 20 mg qn and Probucol 0.25 g/bid; Intensively combining treatment group (n=79): Atorvastatin 40 mg qn and Probucol 0.5 g/bid, with a further dose of Atorvastatin 40 mg and Probucol 0.5 g 2 h before the angioplasty; Intensive Atorvastatin group (n=74): Atorvastatin 40 mg qn, with a futher dose of Atorvastatin 40 mg 2 h before the angioplasty. Blood urea nitrogen (BUN), serum creatinine (Scr), serum uric acid (SUA), and estimated glomerular filtration rate (eGFR) (through MDRD method) of all patients were tested at the times of 24 h before and 24 h after the procedure. Results (1) After operation, BUN of all groups decreased; Scr in Standard combining treatment group and Intensive Atorvastatin group increased significantly; while eGFR decreased only in Standard combining treatment group (p 0.05); (2) SUA in Standard combining treatment group and Intensively combining treatment group decreased significantly after operation (p 0.05). (3) For hypertensive patients, Scr in Standard combining treatment group and Intensive Atorvastatin group increased significantly (p Conclusions Preoperative combination treatment of Atorvastatin and Probucol could reduce perioperative serum uric acid9s level, what9s more with a intensive treatment of future dose of Atorvastatin 40 mg and Probucol 0.5 g 2 h before the angioplasty could also improve CIAKI. For hypertensive patients, intensively combining treatment could not only reduce serum uric acid9s level, but also improve CIAKI.