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The reaction of aromatic dialdehydes with enantiopure 1,2-diamines: an expeditious route to enantiopure tricyclic amidines
- Source :
- Tetrahedron: Asymmetry. 21:2911-2919
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The condensation of enantiopure 1,2-diamines with terephthalaldehyde, isophthalaldehyde or 2-iodo-, 2-alkyl- or 2-aryl-1,3-benzenedialdehydes in toluene followed by treatment with NBS in dichloromethane gives direct access to enantiopure 1,4-, and 1,3-di(4,5-dihydro-1H-imidazol-2-yl)benzenes (diamidines). The condensation of o-phthalaldehyde, and other ortho-disubstituted aromatic dialdehydes, with enantiopure 1,2-diamines, without NBS, gives enantiopure 3,5-dihydro-2H-imidazol-[2,1]-isoindoles.
Details
- ISSN :
- 09574166
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Tetrahedron: Asymmetry
- Accession number :
- edsair.doi...........ad61afd462e02dff0c7df16956758a7f
- Full Text :
- https://doi.org/10.1016/j.tetasy.2010.12.002