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5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
- Source :
- IUPHAR/BPS Guide to Pharmacology CITE. 2019
- Publication Year :
- 2019
- Publisher :
- Edinburgh University Library, 2019.
-
Abstract
- 5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 482]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [463, 382]).
Details
- ISSN :
- 26331020
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- IUPHAR/BPS Guide to Pharmacology CITE
- Accession number :
- edsair.doi...........acc171822fcb3a73f3b0da9179a7a21b