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Risk Factors for Pneumocystis jiroveci Pneumonia in Glomerulonephritis Patients Receiving Immunosuppressants
- Source :
- Internal Medicine. 51:2869-2875
- Publication Year :
- 2012
- Publisher :
- Japanese Society of Internal Medicine, 2012.
-
Abstract
- OBJECTIVE: Pneumocystis jiroveci pneumonia (PJP) infection is a rare but lethal complication in immunocompromised hosts. However, risk factors for PJP infection in glomerulonephritis (GN) patients receiving immunosuppressants are unknown. METHODS: From August 2009 to July 2010, we encountered a cluster occurrence of PJP infection in our renal biopsy patients. Seven of 73 GN patients under immunosuppressant agents developed PJP infection, which were diagnosed by the Giemsa and Gomori's methenamine silver stains of the bronchoalveolar lavage specimen. RESULTS: The average time of PJP onset was 2.4 months after immunosuppressant initiation. We found that the immunosuppressant regimens were equal between patients with and without the development of PJP infection regarding the daily dose per body weight, treatment duration, and accumulative dose per body weight. Logistic regression analysis indicated that high serum creatinine, low hemoglobin, and low absolute lymphocyte count at immunosuppressant initiation, and high chronicity indices of kidney pathology were predictors of PJP infection. In addition, patients with PJP infection had persistently worse renal function, more severe anemia, and more severe lymphocytopenia as compared to those without. CONCLUSION: Prophylactic therapy for P. jiroveci and immunosuppressant dose reduction should be considered in GN patients with high chronicity of their kidney diseases and/or persistent lymphocytopenia.
- Subjects :
- medicine.medical_specialty
Creatinine
medicine.diagnostic_test
biology
business.industry
Renal function
General Medicine
medicine.disease
biology.organism_classification
Gastroenterology
chemistry.chemical_compound
Pneumonia
Bronchoalveolar lavage
chemistry
Internal medicine
Immunology
Internal Medicine
medicine
Pneumocystis jirovecii
Renal biopsy
Lymphocytopenia
Complication
business
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi...........acad7a385460c32205a815f3438fc7e2