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Synthesis of 14C-labelled (R)-α-amino-6,7-dimethyl-3-(phosphonomethyl)-2-quinolinepropanoic acid
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 39:259-266
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- The NMDA antagonist (R)-α-amino-6,7-dimethyl-3-(phosphonomethyl)-quinolinepropanoic acid 1 was [ 14 C]-labelled at the 6-methyl group. The quinoline synthesis started from 4-bromo3-methylaniline and the radiolabel was introduced late in the synthetic scheme. The synthesis was accomplished by a NiCl2(dppp)2-catalyzed coupling of the 6-bromoquinoline derivative 6 with a zinc reagent made from [ 14 C]-methyl iodide.
- Subjects :
- chemistry.chemical_classification
Bicyclic molecule
Stereochemistry
Organic Chemistry
Quinoline
Iodide
chemistry.chemical_element
Zinc
Biochemistry
Chemical synthesis
Analytical Chemistry
chemistry.chemical_compound
chemistry
Reagent
Drug Discovery
Radiology, Nuclear Medicine and imaging
Carbon-14
Spectroscopy
Derivative (chemistry)
Subjects
Details
- ISSN :
- 03624803
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi...........aca53bfa7c94ab0abdc3652a9a44aed0