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Increased PLA2 activity in individuals at ultra-high risk for psychosis
- Source :
- European Archives of Psychiatry and Clinical Neuroscience. 271:1593-1599
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Phospholipase A2 is the main enzyme in the metabolism of membrane phospholipids. It comprises a family of enzymes divided into iPLA2, cPLA2 and sPLA2. Studies have reported increased PLA2 activity in psychotic patients, which suggests an accelerated breakdown of membrane phospholipids. In the present study we investigated whether increased PLA2 activity is also present in individuals at ultra-high risk (UHR) for psychosis. One-hundred fifty adults were included in this study (85 UHR and 65 controls). UHR was assessed using the “structured interview for prodromal syndromes”. PLA2 activity was determined in platelets by a radio-enzymatic assay. We found in UHR individuals increased activities of iPLA2 (p
- Subjects :
- medicine.medical_specialty
Psychosis
biology
business.industry
Prodromal Syndromes
General Medicine
Ultra high risk
medicine.disease
030227 psychiatry
03 medical and health sciences
Psychiatry and Mental health
0302 clinical medicine
Endocrinology
Phospholipase A2
Internal medicine
medicine
biology.protein
lipids (amino acids, peptides, and proteins)
Pharmacology (medical)
Platelet
sense organs
business
030217 neurology & neurosurgery
Biological Psychiatry
Subjects
Details
- ISSN :
- 14338491 and 09401334
- Volume :
- 271
- Database :
- OpenAIRE
- Journal :
- European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi...........ac29fac9139ca0a6211efd960a262262