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Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report
- Source :
- Journal of Neurosurgery: Spine. 34:254-258
- Publication Year :
- 2021
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2021.
-
Abstract
- This study describes a patient with an autograft-derived spinal cord mass following transplantation of olfactory mucosa for treatment of cervical spine injury. The authors report the case of a 35-year-old man who suffered a complete spinal cord injury (SCI) at C5–6 in 2001. The patient underwent an olfactory mucosal cell implantation at the location of injury 4 years following initial trauma. Twelve years later, the patient presented with rapidly progressive decline in upper-extremity function as well as neuropathic pain. Imaging revealed a heterogeneously enhancing intramedullary mass from C3 to C7. At surgery, the patient was found to have a posttransplant mucinous mass. Each mucinous cyst was drained and a portion of the cyst wall was removed. Histological examination demonstrated ciliated epithelium-lined fibrous tissue, submucosal glands, and mucoid material, consistent with a transplant-derived tumor. This case report both documents a rare long-term complication of olfactory mucosal cell transplantation and serves as a cautionary tale encouraging prudent use of novel treatments in a vulnerable population of patients with severe SCI.
- Subjects :
- Submucosal glands
medicine.medical_specialty
business.industry
General Medicine
Spinal cord
medicine.disease
Surgery
law.invention
Intramedullary rod
Transplantation
03 medical and health sciences
Olfactory mucosa
0302 clinical medicine
medicine.anatomical_structure
law
030220 oncology & carcinogenesis
Neuropathic pain
medicine
business
Complication
Spinal cord injury
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15475654
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Neurosurgery: Spine
- Accession number :
- edsair.doi...........abd5afd8a3ee170de7a025e3f09b74e1