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Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report

Authors :
Mary In-Ping Huang Cobb
Stephen C. Harward
Eric R. Butler
Shervin Rahimpour
Thomas J. Cummings
Allan H. Friedman
Theresa Williamson
Andrew Cutler
Source :
Journal of Neurosurgery: Spine. 34:254-258
Publication Year :
2021
Publisher :
Journal of Neurosurgery Publishing Group (JNSPG), 2021.

Abstract

This study describes a patient with an autograft-derived spinal cord mass following transplantation of olfactory mucosa for treatment of cervical spine injury. The authors report the case of a 35-year-old man who suffered a complete spinal cord injury (SCI) at C5–6 in 2001. The patient underwent an olfactory mucosal cell implantation at the location of injury 4 years following initial trauma. Twelve years later, the patient presented with rapidly progressive decline in upper-extremity function as well as neuropathic pain. Imaging revealed a heterogeneously enhancing intramedullary mass from C3 to C7. At surgery, the patient was found to have a posttransplant mucinous mass. Each mucinous cyst was drained and a portion of the cyst wall was removed. Histological examination demonstrated ciliated epithelium-lined fibrous tissue, submucosal glands, and mucoid material, consistent with a transplant-derived tumor. This case report both documents a rare long-term complication of olfactory mucosal cell transplantation and serves as a cautionary tale encouraging prudent use of novel treatments in a vulnerable population of patients with severe SCI.

Details

ISSN :
15475654
Volume :
34
Database :
OpenAIRE
Journal :
Journal of Neurosurgery: Spine
Accession number :
edsair.doi...........abd5afd8a3ee170de7a025e3f09b74e1