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Prognostic Value ofEGFRExon-20 Insertions in Czech Patients With Advanced Non-small Cell Lung Cancer
- Source :
- Anticancer Research. 41:5625-5634
- Publication Year :
- 2021
- Publisher :
- Anticancer Research USA Inc., 2021.
-
Abstract
- Background/aim Per literature, patients with epidermal growth factor receptor (EGFR) exon-20 insertions respond poorly to tyrosine kinase inhibitors (TKIs). This study analyzed real-world data to examine the prognostic and predictive value of these mutations. Patients and methods We conducted a retrospective cohort study using Czech TULUNG Registry data, with data on multiple mutation types, collected in 2011-2020. Results We analyzed 554 (95.85%) patients with EGFR exon-19 deletions or exon-21 L858R substitutions and 24 (4.15%) patients with exon-20 insertions who received first-line high-value therapies. We summarized clinical characteristics and outcomes in all patients and by cohort. The risk of progression was statistically significantly higher (86%) in the exon-20 insertion cohort compared to the cohort with other mutations. Although not statistically significant, the risk of death was 44% higher in patients with exon-20 insertions. Conclusion Advanced NSCLC patients with rare EGFR exon-20 insertions have a high risk of progression.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Mutation
biology
business.industry
Retrospective cohort study
General Medicine
medicine.disease_cause
medicine.disease
Exon
Internal medicine
Cohort
medicine
biology.protein
Non small cell
Epidermal growth factor receptor
business
Lung cancer
Tyrosine kinase
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi...........aba859470439e22e1b459a0e725153a0
- Full Text :
- https://doi.org/10.21873/anticanres.15378