18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy

Authors :: Giampiero Giovacchini
Clarissa J. Liew
William H. Theodore
Robert Bonwetsch
Irene Dustin
Susumu Sato
Patricia Reeves-Tyer
Anto Bagic
Peter Herscovitch
Sadat Shamim
Young-Min Lim
Source :: Epilepsia. 50:234-239
Publication Year :: 2009
Publisher :: Wiley, 2009.
Abstract: Background Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) shows widespread hypometabolism even in temporal lobe epilepsy (TLE) patients with mesial temporal foci. 18F-trans-4-fluoro-N-2-[4-(2-methoxyphenyl) piperazin-1-yl]ethyl-N-(2-pyridyl)cyclohexanecarboxamide (18F-FCWAY) PET may show more specific 5-HT1A receptor binding reduction in seizure initiation than propagation regions. 18FCWAY PET might be valuable for detecting epileptic foci, and distinguishing mesial from lateral temporal foci in MRI negative TLE patients.