Correlation between Measurement of Lung Diffusion Capacity Using Single Breath Methods (DLCO-SB) and COPD Group in Persahabatan Hospital Jakarta

Background: This is a preliminary study to measure DLCO-SB in COPD patients in Persahabatan Hospital to know the magnitude of disturbance in diffusing capacity of the lung in COPD patients. Methods: This was a cross sectional study in which COPD patients attending COPD-Asthma clinic in Persahabatan Hospital Jakarta were performed spirometry and DLCO-SB consecutively between May 2015–July 2015. Comorbidities conditions were also recorded. Results: Spirometry and DLCO-SB measurement were conducted on 65 COPD subjects of which 10.8% subjects were COPD Group A, 29.2% were Group B, 32.3% were COPD group C and 27.7% were COPD group D. The mean age was 64.15; mean FEV1% was 46.05%, mean DLCO measured was 19.42 ml/min/mmHg and the mean DLCO% was 72.00%. The proportion of decreasing in diffusing capacity of the lung in COPD patients was 56.92%. There was significant correlation between grup COPD, GOLD COPD gade, VEP1, BMI and comorbidities with magnitude of decresing DLCOvalue. There were no correlation between DLCO value with sex, smoking history, brinkmann index, age, obstruction-mix criteria, comorbidities and length of COPD period. Conclusion: The proportion of decreasing in DLCO in COPD patients was 56.92%. There was significant correlation between grup COPD, GOLD COPD gade, VEP1, BMI and previous TB history with magnitude of decresing DLCOvalue.