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Thalassemia, Protein C, Protein S and Infarct: Correlation?
- Source :
- The Indian Journal of Pediatrics. 77:1047-1047
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Sir, I read the report on an interesting case of beta-thalassemia/ hemoglobin E (b-thal/HbE) by Vineeta et al. with a great interest [1]. Vineeta et al. concluded that “Protein C and Protein S deficiency were the causative factor for developing hemorrhagic infarct in the HbE/ Beta thalassemia patient [1].” In fact, it can be confirmed that there existed a case of a combined genetic disorder between HbE and IVS1-5 mutation. However, the conclusion proposed by Vineeta et al. should be carefully considered. Firstly, a single case report is not a standard report to set any correlation in clinic. A systematic case control study must be performed to get the cause and outcome relationship. Secondly, the hemorrhagic infarct has no doubt related to abnormal Protein C and Protein S, but further referred linkage to b-thalassemia/HbE cannot be directly assumed. There must be a complete proposed biological process based on gene ontology principle to confirm this correlation.
- Subjects :
- medicine.medical_specialty
Mutation
biology
business.industry
Thalassemia
Beta thalassemia
Hemorrhagic infarct
medicine.disease_cause
medicine.disease
Gastroenterology
Protein S
Internal medicine
Pediatrics, Perinatology and Child Health
Hemoglobin E
medicine
biology.protein
Protein S deficiency
business
Protein C
medicine.drug
Subjects
Details
- ISSN :
- 09737693 and 00195456
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- The Indian Journal of Pediatrics
- Accession number :
- edsair.doi...........ab21363ce870cbe2aa3b7466c461aa79