Some metal(II) chelates of 4-(m-aminophenyl)-2-formylpyridine thiosemicarbazone: Their preparation, characterizafion and antitumour activity

Complexes of Co(Il), Ni(II), Cu(II), Zn(II) and Pt(II) with 4-( m -aminophenyl)-2-formylpyridine thiosemicarbazone (4- m -NH 2 ph-2-pytsc-H) were isolated and characterized by elemental analysis, conductance measurements, magnetic susceptibilities (from room temperature to liquid N 2 temperature), diffuse reflectance and infrared studies. On the basis of these studies a distorted trigonal-bipyramidal structure for [M(4- m -NH 2 ph-2-pytsc-H)Cl 2 ] (M = Co(II), Ni(II) or Cu(II)), [Zn(4- m -NH 2 ph-2-pytsc-H)(OAc) 2 ] and a square-planar structure for [Pt(4- m -NH 2 ph-2- pytsc)Cl] are suggested. All these metal(II) chelates were screened for their antitumour activity in the P388 lymphocytic leukaemia test system in mice, and were found to possess no significant activity at the dosages employed.