The elucidation of the primary structure of the hypothalamic thyroid stimulating hormone releasing factor of ovine origin by means of mass spectrometry

This paper illustrates the role that mass spectrometry played in the first elucidation of the primary structure of a hypothalamic releasing factor. It has been demonstrated that ovine TRF has the structure 2-pyrrolidone-5-carboxylyl-histidyl-proline amide.